Integrated molecular, epigenetic, microbial and liquid biopsy biomarkers in colorectal cancer: implications for prognosis and precision therapy
Abstract Background Colorectal cancer (CRC) is a biologically diverse malignancy driven by a complex interplay of genetic mutations, epigenetic changes, tumour microenvironmental factors and host–microbial interactions. Foundational molecular events including APC-associated Wnt/β-catenin dysregulation, TP53 inactivatio...