ABSTRACT The lateral patch epitope of the H1 hemagglutinin (HA) was a dominant target of antibodies following exposure to the 2009 pandemic H1N1 virus. However, the conservation and mechanisms of antigenic drift in the lateral patch remain unresolved. Here, we used lateral patch-specific monoclonal antibodies (mAbs) to...
Jordan I. Lemus-Reyes, Monica L. Fernández-Quintero, Edgardo Ayala et al.· Journal of Virology· 0 citations
A major goal for hepatitis C virus (HCV) vaccine development is to elicit broadly neutralizing antibodies (bNAbs) against the E1E2 glycoprotein complex located on the viral surface. Inducing HCV bNAbs requires engagement of their germline B cell precursors. HCV glycoproteins usually do not bind and activate inferred ge...
Fabian Mulder, F. Cannac, Joan Capella-Pujol et al.· bioRxiv· 0 citations
Evaluated the accuracy of AlphaFold 3 (AF3) in predicting immune complexes of a known class of bnAbs towards a conserved epitope on influenza hemagglutinin (HA) and resolved atomistic details with high-resolution SPA cryo-EM that explain challenges with AF3 immune complex prediction.
Morgan Gee, Pragati Sharma, Alesandra J. Rodriguez et al.· Journal of Immunology· 0 citations
A systematic comparison is made between PIEZO1 reconstituted in detergent micelles and in cell membrane–derived nanodiscs, establishing native membranes as critical determinants for mechanotransduction.
Sanjai Karanth, Alessandro Nicoli, F. Cannac et al.· bioRxiv· 0 citations
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