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Author

A. Wheatley

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Open access Jul 2026

Epistasis facilitates the long-term antigenic evolution of the influenza B virus hemagglutinin

This study identifies critical similarities and differences with A(H3N2) evolution and demonstrates the role of epistasis in balancing antigenic novelty with viral fitness, and supports the development of genotype-to-phenotype prediction tools, but such predictions need to capture the complex outcomes of epistasis.

Lara S. U. Schwab, Ruo-Peng Xie, Ellie Reilly et al. · 0 citations
Open access Sep 2026

Immunogen selection and prior immunity shape antibody breadth following immunisation with avian H5 hemagglutinin

A considerable variability in the potential of H5 vaccine antigens to induce neutralisation breadth is demonstrated, as well as the potential for multivalent vaccines and ferritin nanoparticle-based strategies to robustly augment immunity across antigenic variants.

Yee-Chen Liu, Andrew Kelly, R. Esterbauer et al. · 0 citations

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