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Open access Aug 2026

Visualizing zinc-starved slow-replicating Mycobacterium tuberculosis in neutrophil-rich lung lesions

The months-long treatment for tuberculosis is partially attributed to a minor Mycobacterium tuberculosis (Mtb) subpopulation exhibiting phenotypic drug resistance, although origins of these bacilli in hosts remain unknown. Previously, we observed that mycobacteria respond to growth-restrictive limitations of zinc by ac...

Jamie H. Corro, Jordan Holl, V. Patil et al. · 0 citations
Open access Aug 2026

Desiccation promotes DNA damage and rifampin resistance in Mycobacterium tuberculosis.

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen that depends on its ability to spread from host to host to survive as a species. Knowledge of traits supporting transmission is lacking. Here, because desiccation occurs during the generation of Mtb-transmitting aerosol droplets, we exposed Mtb mounted atop...

C. Brown, Brendon M. Lee, H. M. Liu et al. · 1 citation

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