miR149-5p: A hepatocyte EXOmotif sequence containing microRNA that attenuates liver fibrosis by specifically targeting PDGFRB in HSCs.
INTRODUCTION Liver fibrosis is a progressive pathological process driven by liver injury, including viral hepatitis and metabolic dysfunction-associated steatohepatitis (MASH), and can progress to cirrhosis, liver failure, and hepatocellular carcinoma (HCC). Hepatocyte-hepatic stellate cell (HSC) crosstalk plays a cent...