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Author

A. Yaacov

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Case report Open access Aug 2026

Emergence of EGFR C797S as a resistance mechanism to CLN081 in EGFR exon 20–mutant NSCLC: case report

EGFR exon 20 insertion mutations represent a distinct subset of non–small cell lung cancer (NSCLC) with limited sensitivity to earlier-generation EGFR tyrosine kinase inhibitors (TKIs). CLN081 (zipalertinib; TAS6417) is a novel covalent EGFR TKI under development with activity against EGFR exon 20 insertion variants. W...

Basil Dabbah, R. Gillis, Jaber Salim et al. · 0 citations
Open access Aug 2026

Genomic subtypes inferred from clinical sequencing provide significant prognostic stratification in metastatic breast cancer

Purpose. The 11 Integrative Cluster (IntClust) genomic subtypes of breast cancer have both prognostic and predictive value but require integrated DNA copy-number and gene expression profiling, which are not routinely used in clinical care. We tested whether IntClust could be inferred from clinical DNA targeted gene pan...

A. Yaacov, A. Grinshpun, P. Pharoah et al. · 0 citations

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