Open access
Oct 2026
Adolescent social isolation drives sex-dependent shifts in medial prefrontal cortex endocannabinoid tone and excitatory/inhibitory balance: the protective role of a methyl donor.
Prolonged social isolation triggers neuropsychiatric impairments linked to brain neurotransmitter imbalances. This study investigated the impact of social isolation on sensory perception, affective states, and the levels of amino acid neurotransmitters and endocannabinoids within the medial prefrontal cortex (mPFC) of...
Federica Ricciardi, Laura Mosca, C. Belardo et al.
· Neuropharmacology · 0 citations