Author

A. Zwartsen

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Review Open access Sep 2026

Extrapolation steps in quantitative in vitro to in vivo extrapolation to advance in vitro-based chemical risk assessment for human health

The transition towards Next Generation Risk Assessment (NGRA) aims at increasing human relevance and efficiency of chemical risk assessment, by using human-based in vitro and in silico methods. Quantitative in vitro to in vivo Extrapolation (QIVIVE) is central to this approach and enables the derivation of health-based...

M. J. M. Benschop, J. Minnema, E. Kasteel et al. · Current Research in Toxicolo... · 0 citations

Open access Aug 2026

Update of the 2025 and 2026 standard regulatory actions for prospective and retrospective cumulative dietary risk assessment of pesticides in MCRA

Abstract Regulatory concern over human exposure to chemical mixtures has intensified, as individuals are continuously exposed to multiple chemical substances from various sources. Historically, the European Food Safety Authority (EFSA) assesses risks based on individual chemicals or expected co‐occurring groups of chem...

M. Schepens, J. Kruisselbrink, G. van Donkersgoed et al. · EFSA Supporting Publications · 0 citations