Aamir Saeed

Binding Does Not Mean Stabilizing: High-Affinity Porphyrins Exhibit Opposite Effects on G‑Quadruplex Stability

Binding affinity is often used as a predictor of G-quadruplex (G4) stabilization. Here, we show that ligand binding and quadruplex stabilization can be thermodynamically decoupled. Two closely related tetracationic porphyrins bind the human telomeric G4 with comparable affinities approaching 106 M–1 but induce opposite...