Open access
Aug 2026
Conformational selection drives substrate-ATP coupling in the type VI ABC transporter
These findings establish the coupling helices as dynamic allosteric elements that integrate nucleotide and substrate binding through conformational selection, providing a mechanistic framework for substrate–ATP coupling in ABC transporters.
S. Seidl, Aaron Klausnitzer, Jagdeep Kaur et al.
· bioRxiv · 0 citations