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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Aaron T. Balana

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Open access Aug 2026

Enhancing De Novo Designed Peptides and Proteins via Irreversible Covalent Isoquinolinium Capture

Irreversible covalent inhibitors have garnered significant attention in recent years. Despite encouraging progress, the vast majority contain electrophiles that target the least abundant amino acid cysteine, substantially limiting target inhibitor design for therapeutic intervention. Here, we generalize 2-ethynylbenzal...

Paul M. Levine, Patrick W. Erickson, Timothy W. Craven et al. · 0 citations

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