Author

Abdullah Kahraman

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Open access Oct 2026

Switches in alternatively spliced isoforms impact protein and drug interactions in melanoma, ovarian cancer, and acute myeloid leukemia.

BACKGROUND Alternative splicing is a cellular process and a primary source of proteome diversity. Switches in the Most Dominant Transcript (MDT), where the predominantly expressed isoform changes between normal and cancer samples, have been implicated in disrupting protein interaction networks and driving tumour progre...

Tülay Karakulak, H. Moch, C. von Mering et al. · British Journal of Cancer · 0 citations

Open access Jul 2026

A tumor profiling resource for ovarian cancer: insights into chemotherapy-driven heterogeneity and personalized treatment strategy

It is demonstrated that integrated multimodal tumor profiling can inform personalized maintenance treatment decisions and that chemotherapy reshapes tumor cell diversity.

Francis Jacob, R. Wegmann, Joanna Ficek-Pascual et al. · Nature Communications · 0 citations

Open access Sep 2026

SPLISOFORMS: a Structure-Resolved Knowledge Base of Alternative Splicing Isoforms

Background Alternative splicing expands the coding capacity of single genes into diverse protein families, and its dysregulation is a recognized hallmark of cancer. Despite this, the characterization of splice variants is largely restricted to sequence-level annotations. The functional consequences of an isoform, such...

Jakob Steuer, Abdullah Kahraman · bioRxiv · 0 citations