A novel series of six imidazopyridine-based chalcone hybrids is synthesized and evaluated their in vitro biological activities, including total antioxidant capacity, iron-reducing power, and radical scavenging (DPPH, ABTS, NO), as well as antidiabetic potential against α-amylase, α-glucosidase, and aldose reductase.
Hanan Abdelmawgoud Atia, Aladdin M. Srour, Hanaa Farag et al.· Scientific Reports· 0 citations
The consistent binding of compound 5 d within the ATP‐binding pocket of CDK‐2 was confirmed by molecular docking and molecular dynamics simulations, and attractive drug‐like and pharmacokinetic features, similar to those of Roscovitine, were demonstrated by in silico ADMET predictions.
Wagdy M. Eldehna, Zainab M. Elsayed, Mohamed R. Elnagar et al.· Drug development research (P...· 0 citations
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