Abdunnaser Abdunnaser Megrahi

Design and In Silico Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Potential CYP51B Inhibitors Against Aspergillus fumigatus

Antifungal resistance and invasive fungal infections remain the major therapeutic issues, especially in patients with impaired immune systems. Aspergillus fumigatus is the main cause of invasive aspergillosis and sterol 14-α-demethylase (CYP51B), a key enzyme in the biosynthetic pathway of ergosterol, is an important t...