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Author

Abhay Kotecha

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2 papers indexed here

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Open access Oct 2026

Mechanisms of intracellular pH gating and local anesthetic inhibition of the two-pore domain K+ channel TASK-2.

TWIK-related acid-sensitive K+ channel 2 (TASK-2) is a pH sensing two-pore K+ (K2P) channel that regulates respiration in brainstem neurons and systemic pH homeostasis in kidney. Despite its physiological importance and implication in disease, the molecular basis for intracellular gating and pharmacological inhibition...

Trevor A. Docter, B. Sorum, Bao-Bin Li et al. · 0 citations
Open access Sep 2026

Ligand-induced activation of RyR1 in native membranes

Synchronized calcium release through arrays of the ryanodine receptor RyR1, fundamental to skeletal muscle excitation-contraction coupling, is achieved through the mechanical interaction of RyR1s and voltage-sensing receptors DHPR that activate RyR1s in response to action potentials. The calcium release is enhanced thr...

Vasilii Mikirtumov, Sabrina Golusik, Rui-Feng Huo et al. · 0 citations

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