Abhijit Sarkar

AlphaFold 3 prediction of TCR mimic Fv – pMHC complex structures and their validation and optimization

ABSTRACT Monoclonal antibody-derived chimeric antigen receptors (CAR) that mimic T‑cell receptors (TCR) on binding to peptide-major histocompatibility complex (pMHC) and activating T‑cell functions hold great promise for the development of effective immunotherapy. This study applied AlphaFold 3 (AF3) to model the quate...