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Author

Abhilesh Dhawanjewar

2 papers indexed here

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Open access Sep 2026

Tissue-wide metabolic buffering confers resilience to mitochondrial dysfunction

Mitochondria and oxidative phosphorylation (OxPhos) are essential for cellular homeostasis. However, the phenotypes caused by mitochondrial dysfunction often display remarkable tissue-specificity. What determines the susceptibility of individual cells to metabolic or mitochondrial defects in a complex in vivo tissue co...

S. Petridi, Abhilesh Dhawanjewar, Dnyanesh Dubal et al. · 0 citations
Open access Sep 2026

mRNA-LNP therapy restores systemic nucleoside imbalance in a mitochondrial DNA depletion syndrome

Mitochondrial DNA depletion syndromes (MDS) are inherited conditions caused by pathogenic variants in mitochondrial DNA maintenance genes. Most MDS are severe, fatal and incurable conditions. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an MDS resulting from loss-of-function mutations in the TYMP ge...

Nissa L. Carrodus, Jenny J. Yang, Javier Ramón et al. · 0 citations

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