Achuthan Raja Venkatesh

Multiscale spatial analysis implicates chromosomal metaloops in gene patterning across the Drosophila brain

Scores of chromosome-scale loops, or metaloops, arise in the Drosophila brain, but their spatial organization and relationship to neural gene expression patterns remain unclear. Here, we used multiplexed Optical Reconstruction of Chromatin Architecture (ORCA) to examine the multiscale spatial organization of metaloops...