Author

Adam D Norris

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Open access Sep 2026

Spatiotemporal isoform profiling identifies a central activator of microexon splicing in C. elegans

Dynamic alternative splicing programs drive tissue specification and organismal development. Here, we present the most comprehensive, tissue-resolved alternative splicing dataset in Caenorhabditis elegans to date, spanning three major tissue types from early embryogenesis to adulthood. We uncovered broad developmental...

Bina Koterniak, Ernest Liang, Michael Zoberman et al. · bioRxiv · 0 citations

Open access Aug 2026

Hyperactive intestinal proteolysis underlies smn-1 mutant phenotypes

How the ubiquitously-expressed SMN-1 protein is required in a single tissue to avoid degenerative defects caused by hyperactive proteasome activity is revealed, contributing to the understanding of how mutations in ubiquitously-expressed genes can cause highly cell-specific pathologies.

Anusha Iyengar, Lindsey Philips, Adam D. Norris · bioRxiv · 0 citations