Author

Adam DeCosta

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Open access Sep 2026

A mitochondrial insertion directs substrate selection and engagement by the protein unfoldase ClpX.

It is found that the MI is critical for both recruitment and activation of ALAS by S. cerevisiae ClpX, and can serve both to recruit a substrate to mitochondrial ClpX and to accelerate its processing by the AAA+ motor.

Adam DeCosta, Rebekah Barrick, J. Kardon · Journal of Biological Chemis... · 0 citations