Author

Adam M. Saunders

Vanderbilt University

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Preprint Oct 2026

Separating mixtures of single-fiber orientation distributions for increased sensitivity to crossing white matter fibers

Intro: Diffusion MRI allows for in vivo probing of brain tissue architecture via micron-level diffusion aggregated at the millimeter scale, but crossing white matter fibers decrease the sensitivity of downstream tasks such as microstructural modeling and tractography. Current fixel-based methods for identifying the num...

Adam M. Saunders, G. Rudravaram, Michael E. Kim et al. · 0 citations

Open access Sep 2026

Charting confidence in white matter brain charts: enabling study planning through stability validation

Abstract. Purpose Normative modeling of quantitative brain measurements is being widely adopted as a promising method for charting population-level developmental trajectories and identifying abnormalities in groups and individuals. Generalized additive models for location, scale, and shape (GAMLSS) are a statistical fr...

Michael E. Kim, G. Rudravaram, Adam M. Saunders et al. · Journal of Medical Imaging · 0 citations

Open access Jul 2026

A geometric-to-neural cascade for cerebral microbleed detection in susceptibility-weighted MRI

A fully automated, three-stage cascade pipeline that combines subject-adaptive unsupervised candidate generation with two successive lightweight 3D ResNet classifiers, trained with only human-in-the-loop quality-assurance (QA) labels rather than dense voxel-wise segmentation masks is presented.

Sam Bogdanov, G. Rudravaram, Adam M. Saunders et al. · bioRxiv · 0 citations