Oct 2026
LRH-1 is a novel regulator of neutrophil-driven immune responses within the tumor microenvironment.
Plasma cholesterol is correlated with worse outcomes in breast and ovarian cancer. Prior work indicates that myeloid immune cells are highly responsive to cholesterol metabolism. Interestingly, Liver Receptor Homolog-1 (LRH-1, or NR5A2), a key transcriptional regulator of cholesterol homeostasis is highly expressed in...
Yu Wang, Bryan Duong, S. Keeley et al.
· Cancer Letters · 0 citations