A Novel SXXLF Motif in the FXR N‐Terminal Domain Mediates Coregulator and Interdomain Interactions
The nuclear receptor (NR) superfamily is comprised of ligand‐regulated transcription factors that contain an intrinsically disordered domain at the amino‐terminal end, known as the N‐terminal domain (NTD). While this poorly conserved domain is known to possess ligand‐independent activation function (AF‐1), few NTD func...