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Author

Aditi Batra

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2 papers indexed here

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Open access Aug 2026

Antibiotic tolerance due to filamentation shapes β-lactam pharmacodynamics in Escherichia coli

Pharmacodynamic curves describe how changes in drug concentration affect pathogen growth. They are essential for designing treatments that promote pathogen eradication and minimize the evolution of antibiotic resistance. The classical function for modelling pharmacodynamics is a phenomenological, S-shaped curve with st...

Aryan Ramachandran, Josia Pool, A. de Visser et al. · 0 citations
Open access Aug 2026

Experimental evolution of collective β-lactam resistance in Escherichia coli via activation of a dormant outermembrane porin

Understanding the mechanisms that drive antibiotic resistance is relevant for both evolutionary theory and the design of effective drug therapies. A specific challenge are collective resistance mechanisms, where bacterial populations survive drug concentrations that kill individual bacteria. Here, we explore the evolva...

Abraham Ochoa-Guerrero, Joost Hollander, Rotem Gross et al. · 0 citations

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