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Aditya Desai

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Open access 2026

Association Between TWF2 Knockdown and Reduced SNCA Expression: A Screen of 300 CRISPRi Perturbations in Human Embryonic Stem Cells

Elevated α-synuclein, encoded by SNCA, is central to Parkinson’s disease pathology, and lowering SNCA expression is an actively pursued therapeutic strategy. Genes whose inhibition reduces SNCA without broadly disturbing the transcriptome would be useful starting points for experimental follow-up. We analyzed the Arc I...

Aditya Desai, Daniel Plymire · 0 citations

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