Quality-by-Design-Based Development and Optimization of Emtricitabine-Loaded Solid Lipid Nanoparticles
Background: Emtricitabine (FTC) is a nucleoside reverse transcriptase inhibitor widely used in combination antiretroviral therapy for HIV infection. Its pharmacokinetic characteristics and need for regular dosing may affect patient adherence. Solid lipid nanoparticles (SLNs) have been considered beneficial in terms of...