Adrian J. Butcher

Protein Synthesis Dysregulation in Neurodegeneration: Mechanisms, Consequences, and Therapeutic Modulation.

Protein synthesis in neurons is essential for shaping and maintaining the proteome, which underpins synaptic function, learning, memory, and neuronal resilience. Dysregulated mRNA translation control, particularly at the level of initiation, results in reduced global protein synthesis and is a common pathological featu...