Structural Insights into the β-Clasp and Dimerization Interface of Human Ribokinase
Ribokinase (RK), a member of the phosphofructokinase B (PfkB) family, catalyzes the ATP-dependent phosphorylation of d-ribose to ribose-5-phosphate, a step essential for nucleotide biosynthesis and pentose phosphate pathway flux. Because these pathways support redox balance, energy metabolism, and cell proliferation,...