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Author

Adrian Kacperczyk-Perdyan

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Open access Aug 2026

α-Synuclein impairs mitochondrial function and alters cryptochrome regulation in the substantia nigra

Data provide evidence of a specific window of time during which sustained α-synuclein burden results in direct α-synuclein-mitochondria interactions and nigral mitochondrial damage and a specific remodeling of molecular clock components occurs, providing a potential new mechanism contributing to metabolic and mitochond...

S. O’Sullivan, Adrian Kacperczyk-Perdyan, A. Ulusoy et al. · 0 citations
Open access Jul 2026

Oncogenic Kras targeting with MRTX1133 or Daraxonrasib specifically synergize with anti-CTLA4 to promote anti-tumor immunity in pancreatic cancer

It is shown that KRAS targeting with MRTX1133 or Daraxonrasib specifically synergizes with anti-CTLA4, but not other immune checkpoint inhibitors, in inducing tertiary lymphoid structures and promoting anti-tumor immune responses in preclinical pancreatic cancer models.

Krishnan K. Mahadevan, A. S. Maldonado, Bing-Rui Li et al. · 0 citations

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