Open access
Sep 2026
Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation
Abstract Intronic GGGGCC repeat expansions in C9orf72 cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This expansion supports a non-canonical form of translational initiation known as repeat-associated non-AUG (RAN) translation to produce toxic dipeptide repeat proteins that contribute to n...
Clare M. Wieland, Shannon E. Wright, Sydney Willey et al.
· Nucleic Acids Research · 0 citations