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Author

Aeson Chang

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Open access Aug 2026

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids

Significantly enhanced WEE1 inhibitory selectivity over PLK1 was determined for leading macrocycle 2, which also demonstrated broader kinome-wide selectivity and the X-ray cocrystal structure of 2 bound to WEE1 validated its computationally predicted bioactive binding mode.

Joel L Syphers, Josephine A. Wright, Adarsh Kumar et al. · 0 citations
Review Jul 2026

Regulation of solid tumors by the peripheral nervous system.

The nervous system is identified as an upstream regulator of cancer biology and a tractable target for intervention by synthesizing mechanistic insights into how the peripheral nervous system shapes the tumor microenvironment to influence tumor behavior and highlighting emerging therapeutic opportunities to target neur...

Aeson Chang, Shenghong Zhu, Terrance Lam et al. · 0 citations

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