Author

Afaf A. El-Malah

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Open access Sep 2026

Synthesis, in vitro and in silico evaluation of quinazoline and triazoloquinazoline derivatives as PDE7A inhibitors

Background and purpose: Phosphodiesterase 7A (PDE7A) is an attractive therapeutic target for the treatment of inflammatory, autoimmune, and neurodegenerative disorders through modulation of intracellular cAMP levels. However, the development of highly potent and selective PDE7A inhibitors remains challenging. This stud...

Afaf A. El-Malah, M. M. Gineinah, M. Khayat et al. · Research in Pharmaceutical S... · 0 citations

Open access Aug 2026

New quinazoline derivatives with anti-inflammatory activity and computationally predicted PDE7A binding: synthesis, molecular modeling, and in silico pharmacokinetic evaluation

Quinazoline scaffolds are widely recognized in drug discovery for their diverse pharmacological profiles, and several quinazoline derivatives have been reported as phosphodiesterase 7A (PDE7A) inhibitors with potential anti-inflammatory effects. This study aimed to synthesize novel quinazoline derivatives, evaluate the...

Majed A. Alharbi, Ashwaq A. Almagati, M. M. Gineinah et al. · Frontiers in Pharmacology · 0 citations