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Author

AG Mulligan

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Open access Sep 2026

EPS8 dampens the growth dynamics and prolongs the lifetime of actin-based protrusions.

Actin-based membrane protrusions such as filopodia, microvilli, and stereocilia support a range of cell functions, from nutrient absorption to mechanosensation. In each case, membrane deformation is supported by a core bundle of actin filaments, organized in a unipolar 'barbed-end out' manner. Although their structures...

AG Mulligan, Zachary J. Lehmann, Kianna L. Robinson et al. · 0 citations
Open access Aug 2026

InsP3R signaling and actomyosin-dependent mitochondrial dynamics play essential roles in mitochondrial stress-induced longevity

It is shown that ER calcium signalling promotes longevity during mitochondrial stress by regulating actin-dependent mitochondrial remodeling, identifying an inter-organelle signaling axis linking ER calcium release and cytoskeletal remodeling to adaptive mitochondrial responses associated with longevity.

Gao-Min Feng, Elizabeth M. Ruark, AG Mulligan et al. · 0 citations

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