Author

Ahmad Z. Al Meslamani

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Review Open access Sep 2026

From ADA positivity to clinical decision: a context-of-use framework for reflex testing, sampling frequency and stopping rules in immunogenicity assessment.

A context-of-use framework for immunogenicity assessment is proposed for ADA testing, which should be designed around decisions it is expected to support, including pharmacokinetics/, pharmacodynamics (PK/PD) interpretation, efficacy, safety, labeling, dose selection, treatment interruption, and development progression...

Ahmad Z. Al Meslamani, A. Jarab, H. El Sharu et al. · Bioanalysis · 0 citations

Review Open access Aug 2026

Digital twins in precision pharmacotherapy: emerging applications, challenges, and future directions

Digital twin technology, defined as dynamic digital models that represent individual patients, is emerging as a promising paradigm in precision pharmacotherapy. The integration of pharmacokinetic and pharmacodynamic (PK/PD) modeling, clinical data, genomic information, and real-time patient monitoring enables digital t...

A. Jarab, Walid A. Al-Qerem, Hamza Jarab et al. · Frontiers in Digital Health · 1 citation

Review Aug 2026

Developability-by-design for bispecific antibodies in discovery: combining computational prediction and early screening for candidate selection.

This structured narrative review examines literature identified in PubMed/MEDLINE, Embase, Scopus and Web of Science from database inception, supplemented by citation tracking to find developability risks beyond those encountered with conventional monospecific antibodies.

Ahmad Z. Al Meslamani, A. Jarab, Khadeijah Ahmed Al Marshoodi · Expert Opinion on Biological... · 0 citations