Circadian changes in blood pressure are a key factor in determining cardiovascular risk. A normal dipper pattern shows a decrease in blood pressure at night, whereas a non-dipper pattern shows a smaller decrease at night. Changes in the distribution of bodily fluids may affect how blood vessels work and how blood pressure changes over the course of a day. This study aimed to examine the correlation between total body water percentage and circadian blood pressure patterns in individuals classified as prehypertensive. This retrospective cross-sectional study comprised 300 prehypertensive individuals who underwent 24-hour ambulatory blood pressure monitoring and body composition measurement via bioelectrical impedance. Patients were classified into two groups according to the magnitude of nocturnal blood pressure decline: dipper and non-dipper. Clinical, echocardiographic, and hydration characteristics were compared between the dipper and non-dipper groups. In the study population, 124 patients exhibited a dipper pattern, while 176 displayed a non-dipper pattern. Non-dipper patients exhibited a markedly reduced total body water percentage in comparison to dipper persons. Echocardiographic measures, such as interventricular septal thickness and left ventricular end-diastolic diameter, were markedly elevated in the non-dipper cohort. In multivariable logistic regression analysis, total body water percentage persisted as an independent predictor of non-dipper blood pressure pattern. A lower percentage of total body water is linked to a non-dipper blood pressure pattern in individuals who are prehypertensive. These findings indicate that modifications in body fluid content may play a role in circadian blood pressure dysregulation and heightened cardiovascular risk.
Ahmet Cimbek, Ahmet Özderya· OSMANGAZİ JOURNAL OF MEDICIN...· 0 citations
Hematological malignancies are highly heterogeneous diseases characterized by dysregulated signaling pathways and limited durable therapeutic responses. Calcium homeostasis has emerged as a critical regulator of cancer cell fate, yet the role of the sodium/calcium exchanger 1 (NCX1/SLC8A1) in leukemogenesis remains poorly defined. In this study, we comprehensively investigated the biological significance and therapeutic potential of NCX1 across major hematological malignancies by integrating transcriptomic analyses, protein-protein interaction networks, experimental validation, and in silico drug repurposing strategies. NCX1 was highly expressed in HL-60, K-562, and Jurkat cells compared to HaCaT controls. Network analyses revealed that NCX1 interacts with key regulators of calcium signaling, immune response, and signal transduction. In AML and CML patient datasets, a strong positive correlation was observed between NCX1 expression and immune-related pathways, while a negative correlation was observed with translation-related processes. Molecular docking analyses demonstrated that several clinically approved compounds, particularly imatinib and nilotinib, interact with NCX1. Molecular dynamics simulation was performed to evaluate the binding stability and safety of imatinib. Remarkably, the comprehensive analysis showed that imatinib exhibited a stable molecular dynamics profile. All these findings have demonstrated NCX1 as a biologically informative marker of myeloid differentiation and a promising therapeutic weak point within calcium signaling networks in hematological malignancies, providing a rationale for future functional and single-cell validation studies.
Sema Mısır, S. Yaman, Nina Petrović et al.· Biochemical and Biophysical...· 0 citations
