Open access
Jul 2026
Identification of the SARS-CoV-2 genome packaging signal in the nsp12-coding region
A SARS-CoV-2 packaging signal is identified within the nsp12 coding region and shows that the nucleocapsid protein mediates selective genome packaging through its C-terminal domain, establishing the mechanistic basis for SARS-CoV-2 genome packaging and offer a potential antiviral target.
Youngran Park, Jongmin Lim, Hyeonggon Cho et al.
· Nature Communications · 0 citations