Gut microbiota dysbiosis is associated with the synaptic deficits and cognitive impairment induced by LCM mixtures within a proposed mechanistic framework consistent with the AOP concept.
It is found that long-term exposure to LCM mixtures at environmental levels more strongly inhibited viability in hippocampal HT22 cells and microglial BV2 cells than individual compounds, and was associated with memory deficits in mice accompanied by neuroinflammation and reduced hippocampal synaptic plasticity.