Jul 2026
Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity.
Upon viral infection, reduced FLAD1 activity lowered FAD amounts, which removed its inhibitory control over DNA and RNA sensors, thus facilitating extensive interferon-I (IFN-I) signaling activation and strengthening the innate immune response and protected mice from viral infection.
Yao Wang, Yan-Yan Shen, Jia-Yu Liu et al.
· Immunity · 0 citations