Trans-Allosteric Activation Releases Distinct Conformational Traps in Kinase Heterodimers
AlloQuant is established, a computational suite that translates AlphaFold3 structural ensembles into quantitative metrics of kinase regulation, including internal network rigidity, metastable-state populations, and sub-angstrom conformational drivers, establishing AlloQuant as a general framework for quantifying how a...