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Ai-Yuan Wang

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Open access Aug 2026

Stage-dependent upregulation of tumor-derived MDK is associated with CAF state remodeling and an ECM-rich immunosuppressive microenvironment in colorectal cancer

The data support a progression-linked association among tumor-cell-enriched MDK, CAF state remodeling, an ECM-high Fib-WNT5A program, and predicted collagen-mediated immune interactions in CRC.

Xia Liu, Siyuan Ma, Shuai Wu et al. · BMC Cancer · 0 citations