Brucella spp. are intracellular pathogens utilizing a unique, asymmetric cell cycle to survive within host macrophages. While the biogenesis of the replicative niche is well-studied, the intrinsic regulatory circuits that control the Brucella cell cycle remain incompletely understood. Phosphodiesterase (PDEs) modulates...
Jia-Lu Chen, Zheng Dong, Wei Liu et al.· Frontiers in Microbiology· 0 citations
This study developed BP26-OMP16Es, a self-assembling nanoparticle vaccine constructed by fusing immunodominant B- and T-cell epitopes from OMP16 to the self-assembling antigen BP26 via flexible linkers, yielding single-copy and double-copy epitope tandem nanoparticles.
Yun-Yi Zhai, Kai-Hui Sun, G. WuDong et al.· ACS Nano· 0 citations
It is demonstrated that BtpB inhibits M1 polarization in macrophages by regulating STAT3 expression which provides a strong foundation for improved understanding of Brucella infection mechanisms.
Ye Yuan, Ming-Hui Wang, Mingyue Hao et al.· Veterinary Research· 0 citations
This study underscores the role of IgM antibodies in combating Brucella infection, offers insights for antibody-based immunotherapy, and provides a theoretical foundation for developing multi-epitope vaccines based on the conserved epitopes and critical residues.
Yun-Yi Zhai, Kai-Hui Sun, Ye Yuan et al.· BMC Biology· 0 citations
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