Author

Akanksha Arun

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Open access Aug 2026

Morpheus-3D: Structural Diversity-Guided Detection and Localization of Protein Fold Switching

Proteins that reversibly adopt multiple stable folds challenge the classical sequence–structure paradigm, yet their discovery remains limited because fold switching is difficult to detect experimentally and current computational methods fail to resolve the underlying conformationally plastic regions. Here we present Mo...

Sreeharsh Kuniyil, Vijay Subramanian, Akanksha Arun et al. · bioRxiv · 0 citations

Open access Aug 2026

A programmable lipid-triggered allosteric site modulates LC3 LIR receptor binding activity

Membrane recruitment is a fundamental regulator of protein function. However, the allosteric mechanisms by which lipid binding controls protein activity remain poorly understood. In autophagy, the ubiquitin-like protein LC3 is lipid-anchored to autophagosomes, where it is essential for receptor recruitment and vesicle...

Deepanshi Gahlot, Jesu Castin, S. Mathur et al. · Nature Communications · 0 citations