G-protein-coupled receptors (GPCRs) are essential mediators of cellular processes, and their dysfunction is implicated in various diseases. Although pharmacological approaches are powerful for elucidating GPCR functions, careful consideration of potential off-target effects remains crucial. Here, we present an off-targ...
Yuma Matsuoka, Hajime Inoue, Tatsuki Hori et al.· Cell Chemical Biology· 0 citations
Taste receptor type 1 (TAS1R), which consists of sweet and umami receptors in humans, senses nutrients (such as sugars and amino acids) with substrate specificity that is often broad and varies among animals and subtypes. However, the structural basis for achieving diverse specificities remains largely elusive. Here, w...
Rakuto Mizoguchi, Yasuka Toda, M. Nagae et al.· Proceedings of the National...· 0 citations
These findings provide a mechanistic model in which coordinated conformational dynamics across multiple ATPase sites govern dynein's chemomechanical cycle and suggest a dynamic equilibrium between two ADP-bound states.
Hiroshi Imai, R. Kanazawa, Toshihisa Maeshima et al.· Journal of Molecular Biology· 0 citations
GPR84 is an orphan class A GPCR primarily expressed in immune cells, where it plays key roles in inflammation and metabolism. Here, we present the cryo-electron microscopy structures of the GPR84-Gi complex bound to the G protein–biased agonist DL-175, and the inactive state of GPR84 bound to the antagonist GLPG1205. C...
Shota Suzuki, D. Tran, Kouki Nishikawa et al.· Nature Communications· 0 citations
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