Identification of a small-molecule inhibitor of nardilysin and its pharmacological effects on transcriptional regulation and inflammatory arthritis.
Nardilysin (NRDC) is a zinc metallopeptidase of the M16 family that participates in diverse biological processes, including ectodomain shedding and antigen processing. NRDC also functions as a transcriptional coregulator, and this coregulatory activity depends on its metallopeptidase catalytic function. However, small-...