Author

Akira Imamoto

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Open access Aug 2026

Ligand-dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry.

ErbB ligands activate distinct receptor dimers that regulate cell proliferation, but how they influence cell-cycle commitment remains unclear. Here, we show that EGF and HRG induce different modes of G1/S progression in ErbB2-amplified BT474 breast cancer cells. Unexpectedly, HRG, despite activating the more potent Erb...

Ririn Rahamala Febri, Ayaka Nagasato-Ichikawa, Keita Iida et al. · FEBS Letters · 0 citations

Open access Sep 2026

Trans-Allosteric Activation Releases Distinct Conformational Traps in Kinase Heterodimers

AlloQuant is established, a computational suite that translates AlphaFold3 structural ensembles into quantitative metrics of kinase regulation, including internal network rigidity, metastable-state populations, and sub-angstrom conformational drivers, establishing AlloQuant as a general framework for quantifying how a...

Akira Imamoto, Yi-Chao Wu, Ai Shinobu et al. · bioRxiv · 0 citations