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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Akshay Sharma

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Open access Jul 2026

Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans

Treatment with senescence-targeting therapy improves BM hematopoietic stem and progenitor cells in vivo in mice and ex vivo in cells from individuals with SCD and could represent a possible strategy to improve HSPC health, promote manufacture of high quality bespoke clinical products, and potentially enhance the safety...

Aditya Barve, Preeti Dabas, Adam B. Cornwell et al. · 2 citations
Review Open access Jul 2026

Alternative conditioning regimens for hemoglobinopathy gene therapy: balancing efficacy, toxicity, and the next frontier

This review examines the central role of conditioning in enabling durable engraftment of gene-modified hematopoietic stem cells, emphasizing the narrow therapeutic window between insufficient niche clearance and excessive toxicity.

Akshay Sharma, S. Corbacioglu · 0 citations

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