Open access
Jul 2026
Linking zygosity and allelic balance to phenotype with programmable heterozygous editing and allele-specific single-cell RNA sequencing 2307550
An innovative CRISPR-based editing system in primary human T cells is harnessed to engineer heterozygous variants across CARD11, a key regulator of immune signaling, in which heterozygous variants cause diverse IEI with variable penetrance.
Zachary H. Walsh, C. Frangieh, Shudipto Wahed et al.
· Journal of Immunology · 0 citations