Al-Hassan Soliman Wadan

Cancer-associated adipocytes: metabolic reprogramming, crosstalk and therapeutic implications in tumor progression

Adipose tissue, once considered a passive fuel store, is now recognized as a dynamic endocrine organ that shapes cancer behavior. Within the tumor microenvironment (TME), cancer-associated adipocytes (CAAs) undergo marked reprogramming—losing large lipid droplets, adopting fibroblast-like features, and intensifying lip...