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Compound 15c represents a promising PIM-1 kinase inhibitor with potent antiproliferative and pro-apoptotic activities, supporting its potential as a candidate for breast cancer treatment.
A sustainable and environmentally friendly approach for the synthesis of novel pyrimidine Schiff base derivatives through a multicomponent grinding reaction conducted at room temperature under solvent-free conditions is reported, suggesting that compound (3) may serve as a promising lead candidate for breast cancer the...
Compound 4j represents a promising lead candidate for the development of novel EGFR-targeted anticancer agents and demonstrated remarkable potency with an IC50 value of 0.27 µM.
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