Author

Alan J. Emanuel

2 papers indexed here

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Open access Oct 2026

Hyperexcitable primary somatosensory cortex in the MitoPark mouse model of Parkinson’s disease

The majority of Parkinson’s disease patients suffer from decreased tactile acuity or neuropathic pain, both of which contribute to low quality of life and likely exacerbate motor dysfunction. How Parkinson’s disease pathology relates to altered somatosensation remains unclear. One potential contributor is the progressi...

Rong-Hao Zhang, Ruo-Rong Qi, Alan J. Emanuel · bioRxiv · 0 citations

Open access Aug 2026

Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex

Fast-conducting Aβ slowly adapting type I low threshold mechanoreceptors (SAI-LTMRs) and Aβ rapidly adapting type I (RAI-) LTMRs are critical for discriminative touch from glabrous skin. Recent studies used mouse genetic loss-of-function and optogenetic gain-of-function manipulations to determine that signals from thes...

Wanyi Liu, Andrew E. Worthy, Alan J. Emanuel · Journal of Physiology · 0 citations